Pfizer’s coronavirus vaccine relies on a new, unproven technology. A diagram shows how it differs from other candidates.



a hand holding a large pair of scissors: A syringe carrying a vaccine. Carol Smiljan/NurPhoto via Getty Images


© Carol Smiljan/NurPhoto via Getty Images
A syringe carrying a vaccine. Carol Smiljan/NurPhoto via Getty Images

Pfizer is now leading the coronavirus vaccine race: The company announced Monday that people who received its two shots during the company’s final stage of clinical trials were less likely to develop COVID-19. The results indicate the vaccine is more than 90% effective in preventing the disease. 

Like the other leading vaccine candidates in the US, Pfizer’s shot does not inject the actual virus, SARS-CoV-2, into the body, contrary to popular myth. Instead, the vaccines all rely on a harmless segment of the virus to spur the production of antibodies.

But to stimulate that immune response, different vaccines rely on different technologies. Pfizer’s candidate is an mRNA vaccine, an unproven technology that uses a snippet of the coronavirus’ genome to encourage antibody production. Moderna’s uses the same approach, though no mRNA vaccine has

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New study demonstrates candidate’s potential to generate antibodies, limit viral shedding — ScienceDaily

A genetically edited form of a herpes simplex virus — rewired to keep it from taking refuge in the nervous system and eluding an immune response — has outperformed a leading vaccine candidate in a new study from the University of Cincinnati, Northwestern University and the University of Nebraska-Lincoln.

Published Nov. 6 in the journal Nature Vaccines, the study found that vaccinating guinea pigs with the modified live virus significantly increased the production of virus-combating antibodies. When challenged with a virulent strain of herpes simplex virus, the vaccinated animals displayed fewer genital lesions, less viral replication and less of the viral shedding that most readily spreads infection to others.

The modified virus is actually a form of herpes simplex virus type 1, best known for causing cold sores around the lip. The fact that it demonstrated cross-protection against HSV type 2 — the sexually transmitted type usually responsible for

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Candidates agree Biden wants to listen to Fauci

WASHINGTON (AP) — The Latest on the 2020 presidential campaign (all times local):

5:25 p.m.

President Donald Trump is deploying a new attack line against Joe Biden, saying his Democratic presidential opponent “wants to listen to Dr. Fauci.” Biden says that’s correct.

Trump made the comment Monday at a campaign rally in Prescott, Arizona, after criticizing Dr. Anthony Fauci during a conference call with campaign staff. Trump told the staff that Fauci is an “idiot” and a “disaster.”

Fauci is the nation’s top infectious-disease expert and a member of Trump’s White House coronavirus task force. The doctor is both respected and popular, and Trump’s rejection of scientific advice on the pandemic has already drawn bipartisan condemnation.

Biden’s campaign says Trump is using staunch opposition to science as his “closing argument” as Election Day looms. Responding on Twitter to Trump’s accusation that Biden wants to listen to Fauci, Biden wrote, “…yes.”

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