More evidence that cellular ‘death by iron’ could be promising avenue of cancer treatment — ScienceDaily

If there is a silver lining in cancer’s chaotic biology, it’s that the same traits that give cancer cells a growth advantage often present opportunities for sabotaging them.

That’s the central idea behind a new research paper published November 23 in Proceedings of the National Academy of Sciences (PNAS) by Xuejun Jiang, a cell biologist in the Sloan Kettering Institute, and Craig Thompson, President and CEO of Memorial Sloan Kettering. They found that cancer cells often exhibit metabolic changes that make them vulnerable to a particular type of cell death called ferroptosis.

Ferroptosis — literally, death by iron — is often triggered by oxidative stress, the buildup in cells of free radicals and other corrosive chemicals that are byproducts of using oxygen to burn fuel for energy. But many cancer cells, which need abundant amounts of energy to grow and divide, have found a way around this problem.

“Genetic mutations

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Facebook is deleting evidence of war crimes, researchers say

On October 24th, 2020, an art trafficker in Darnah, Libya posted a series of unusual ads. For sale: a Greco-Roman statue, its marble bust covered in a toga. If it looked like it belonged in a museum, that’s because it did. The seller posted photos of the piece in private Facebook groups dedicated to trafficking antiques.

The black market for looted goods is flourishing on Facebook. While the company banned the sale of historical artifacts in June, many of the posts are in Arabic, and Facebook lacks the expertise to properly enforce its new policy.

Photo courtesy of Athar Project

When Facebook is able to identify groups that flout its guidelines, experts say the company simply deletes them, expunging crucial documentation for researchers studying stolen art. “This is critical evidence for repatriation efforts and war crimes,” says Katie Paul, co-director of the Athar Project. “Facebook has created a problem

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Evidence of the interconnectedness of global climate

Evidence of the interconnectedness of global climate
An iceberg in the central Scotia Sea in 2019. Credit: Thomas Ronge

To see how deeply interconnected the planet truly is look no further than the massive ice sheets on the Northern Hemisphere and South Pole.

Thousands of kilometers apart, they are hardly next-door neighbors, but according to new research from a team of international scientists—led by alumna Natalya Gomez Ph.D.’14, and including Harvard professor Jerry X. Mitrovica—what happens in one region has a surprisingly direct and outsized effect on the other, in terms of ice expanding or melting.

The analysis, published in Nature, shows for the first time that changes in the Antarctic ice sheet were caused by the melting of ice sheets in the Northern Hemisphere. The influence was driven by sea-level changes caused by the melting ice in the north during the past 40,000 years. Understanding how this works can help climate scientists grasp future changes and

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First Evidence of a Recently Active Volcano on Mars

The tallest mountain on any of the Solar System’s planets is Olympus Mons, a giant extinct volcano on Mars that is some 14 miles (or 21.9 kilometers) high. That’s about two and a half times the height of Mount Everest. This behemoth formed some 3 billion years ago when the Red Planet was peppered with volcanoes spewing vast quantities of magma across the Martian planes.

Since then, Mars has cooled and become much less active. Indeed, a common view among planetary geologists is that today there are no active volcanoes on Mars.

Olympus Mons -- the largest volcano on Mars (Source: NASA)

Olympus Mons, the largest volcano on Mars. (Source: NASA)

Now that view may have to change thanks to the work of David Horvath at the University of Arizona in Tucson and colleagues. This team has analyzed a region of Mars called Elysium Planitia which is pockmarked by a set of semi-parallel fissures called Cerberus Fossae. The team says

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Trump lawyer ‘got angry’ when pressed for evidence of voter fraud

Fox News host Tucker Carlson on Thursday called out Trump campaign attorney Sidney Powell, saying she “got angry” when he asked her for evidence to support her claims of voter fraud.

Rudy Giuliani standing in front of a crowd: Tucker Carlson: Trump lawyer 'got angry' when pressed for evidence of voter fraud

© Greg Nash
Tucker Carlson: Trump lawyer ‘got angry’ when pressed for evidence of voter fraud

During a press conference earlier in the day with Rudy Giuliani, Powell made the allegation that Denver-based Dominion Voting Systems used technology developed by former Venezuelan President Hugo Chávez, who died in 2013. She claimed votes were manipulated while being tabulated overseas to favor President-elect Joe Biden.

There is no evidence to the claim that votes were manipulated and it has been criticized by a number of conservative officials, including Sen. Joni Ernst (R-Iowa), who on Thursday called it “absolutely outrageous.”

Carlson said he repeatedly reached out to Powell for evidence of her claim and invited her on the show. He said

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Prism Litigation Technology’s Evidence Optix(R) Featured During “Discovery Judge Tank” Event at Georgetown AEDI

Press release content from Accesswire. The AP news staff was not involved in its creation.

Four members of the bench evaluate Evidence Optix’s Proportional Discovery Assessment® technology favorably

CHICAGO, IL / ACCESSWIRE / November 19, 2020 / Prism Litigation Technology, a leading ediscovery advisory firm, today announced it received favorable decisions from all four judges during the Georgetown Law 2020 Global Advanced eDiscovery Institute “Discovery Judge Tank” event.

Modeled after the “Shark Tank” television program, the “Discovery Judge Tank” featured four of the hottest new strategies in ediscovery, including Prism Litigation Technology’s Evidence Optix®, a SAAS-based technology platform that leverages an actionable proportionality methodology to reduce the burden and cost associated with discovery. Mandi Ross, CEO of Prism, “pitched” this solution to the Judge/Shark panel, who then debated the proposed strategies and indicated whether they would “buy” or “pass” on the solution.

Hon. Hildy Bowbeer, U.S.

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Evidence from one of Earth’s biggest underwater landslides ever sheds light on East African rifting

Evidence from one of Earth’s biggest underwater landslides ever sheds light on East African rifting
The figure shows a portion of the Mafia mega-slide imaged by a time-slice extracted from 3-D seismic reflection data (coherence attribute). Credit: Data courtesy of Royal Dutch Shell

A recent study, published in Nature Communications, discovered that earthquakes and continental movements triggered massive underwater landslides tens of millions of years ago off the coast of East Africa—findings that could help assess the future risk of tsunamis to the increasingly populated coastline in the region.

Led by Vittorio Maselli, Canada Research Chair in Coastal Zone Processes and an assistant professor in the Faculty of Science’s Department of Earth and Environmental Sciences, the study is the first to link large-scale submarine mass movements of sediment and rock in the margin slope of the western Indian Ocean with continental rifting and, thus, the formation of a new plate boundary.

With help from industry, Dr. Maselli and his team used seismic data to

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New analysis adds to evidence that that smartphone use is associated with impulsivity — ScienceDaily

In a new study, people who spent more time on their phones — particularly on gaming or social media apps — were more likely to reject larger, delayed rewards in favor of smaller, immediate rewards. Tim van Endert and Peter Mohr of Freie Universität in Berlin, Germany, present these findings in the open-access journal PLOS ONE on November 18, 2020.

Previous research has suggested behavioral similarities between excessive smartphone use and maladaptive behaviors such as alcohol abuse, compulsive gambling, or drug abuse. However, most investigations of excessive smartphone use and personality factors linked to longer screen time have relied on self-reported measurements of smartphone engagement.

To gain further clarity, van Endert and Mohr recruited volunteers who agreed to let the researchers collect actual data on the amount of time they spent on each app on their iPhones for the previous seven to ten days. Usage data was collected from 101

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Evidence of infection caused by Asian virus found in Germany — ScienceDaily

A group of researchers from Charité — Universitätsmedizin Berlin have confirmed Germany’s first-ever case of animal-to-human transmission involving a specific species of virus known as the ‘Seoul virus’. Working alongside colleagues from Friedrich-Loeffer-Institut (FLI), the researchers were able to confirm the presence of the virus in a young female patient and her pet rat. Their findings, which have been published in Emerging Infectious Diseases, may influence the way in which we deal with both wild and domesticated rats.

Following multiple outbreaks earlier in the 21st century, hantavirus disease syndromes have gained increasing levels of public attention and were made notifiable in Germany in 2001. The Puumala and Dobrava-Belgrade viruses, for instance, which are common across central Europe and can be spread by numerous types of mice, usually cause acute fever. Occasionally, infection may result in HFRS (hemorrhagic fever with renal syndrome), an illness characterized by fever, low blood pressure

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Evidence of Neolithic Construction Boom Found at British ‘Mega-Henge’ | Smart News

Thousands of years ago, Neolithic humans in southern Britain constructed some of the most enduring evidence of early civilizations: enormous megaliths, including Stonehenge, used by generations of prehistoric peoples as sites for burials and rituals.

Some historians have argued that Neolithic workers built these henges over the course of centuries. But new research published in Proceedings of the Prehistoric Society suggests that ancient builders actually constructed one such structure—the Mount Pleasant henge just outside of Dorchester, England—in a much speedier timeframe of between 35 and 125 years.

Researchers proposed the revised timeline after radiocarbon dating artifacts recovered from the Mount Pleasant site. Though the items tested were excavated more than 50 years ago, they had not been analyzed with modern dating techniques until now, according to a statement from Wales’ Cardiff University.

As Steven Morris writes for the Guardian, the Mount Pleasant complex originally consisted of a timber-and-stone monument;

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