Repurposed mouse model sheds light on loss of smell in COVID-19 — ScienceDaily

A repurposed mouse model can develop symptoms of both severe COVID-19 (lung damage, blood clots, abnormal blood vessels, and death) and also of milder disease, including loss of the sense of smell, according to a recent University of Iowa study published in Nature.

The study also showed that convalescent plasma from a patient who had recovered from COVID-19 protected the mice against lethal disease. The findings suggest the K18-hACE2 mouse model is useful for understanding a spectrum of COVID-19 disease symptoms, and for developing and testing new treatments.

When COVID-19 started spreading across the world earlier this year, UI researchers Stanley Perlman, MD, PhD, and Paul McCray, MD, realized that a mouse model they had created a decade earlier to study SARS might be an invaluable tool for understanding the concerning new disease and for testing potential treatments.

In the new study, Perlman, McCray, and colleagues present a detailed characterization

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Shrinking massive neural networks used to model language — ScienceDaily

You don’t need a sledgehammer to crack a nut.

Jonathan Frankle is researching artificial intelligence — not noshing pistachios — but the same philosophy applies to his “lottery ticket hypothesis.” It posits that, hidden within massive neural networks, leaner subnetworks can complete the same task more efficiently. The trick is finding those “lucky” subnetworks, dubbed winning lottery tickets.

In a new paper, Frankle and colleagues discovered such subnetworks lurking within BERT, a state-of-the-art neural network approach to natural language processing (NLP). As a branch of artificial intelligence, NLP aims to decipher and analyze human language, with applications like predictive text generation or online chatbots. In computational terms, BERT is bulky, typically demanding supercomputing power unavailable to most users. Access to BERT’s winning lottery ticket could level the playing field, potentially allowing more users to develop effective NLP tools on a smartphone — no sledgehammer needed.

“We’re hitting the point where

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A machine learning model developed in Finland can help us treat cancer more effectively — ScienceDaily

When healthcare professionals treat patients suffering from advanced cancers, they usually need to use a combination of different therapies. In addition to cancer surgery, the patients are often treated with radiation therapy, medication, or both.

Medication can be combined, with different drugs acting on different cancer cells. Combinatorial drug therapies often improve the effectiveness of the treatment and can reduce the harmful side-effects if the dosage of individual drugs can be reduced. However, experimental screening of drug combinations is very slow and expensive, and therefore, often fails to discover the full benefits of combination therapy. With the help of a new machine learning method, one could identify best combinations to selectively kill cancer cells with specific genetic or functional makeup.

Researchers at Aalto University, University of Helsinki and the University of Turku in Finland developed a machine learning model that accurately predicts how combinations of different cancer drugs kill various

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The best model rocket deals and gifts for Cyber Monday

Everybody loves a good rocket launch, and these model rockets will be a good boost to your spacefaring dreams. 



a close up of a colorful background: Estes V2 Semi Scale Model Rocket


© Provided by Space
Estes V2 Semi Scale Model Rocket

The rocket sets below range from beginner to advanced, from air-powered to engine-powered, with some fun variations in between (like rocket-powered cars or rocket-powered bottles.)

Model rocketry requires not only the rocket, but some accessories like wadding, fin straighteners, engines and batteries, so be sure to read the instructions carefully. We’ve included a selection of accessories to help you build out your rocket stable. Also make sure to follow all safety guidelines carefully when launching.

Rocketry is not only a fun activity, but it is a real-life inspiration to help youngsters learn about science, engineering, mathematics and technology (STEM). And many people who flew into space or who worked for space agencies or companies began just like you want to, with

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Tesla Model 3 Vs. Chevy Bolt

The base Tesla Model 3 is a great EV deal and the 2020 Chevrolet Bolt is dirt cheap by electric car standards.

The good news about the cheapest Tesla Model 3 is that it now has acceptable range. The base Model 3 back in 2017 only offered 220 miles of range, now it’s 263 miles.

And while the 2020 Chevy Bolt has always been affordable, it’s now seeing steep discounts making it one of the best EV deals in the U.S.

Very different cars:

The Model 3 is a sedan, the Bolt a compact hatchback. That’s the most glaring difference. Less obvious is the charging network: when you buy a Tesla you also get the Supercharger network. For long-distance drivers that’s almost as important as the car.

Tesla’s Autopilot, an advanced driver-assist technology that’s standard with

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Oklahoma State vs. Texas Tech odds, line: 2020 college football picks, Week 13 predictions from proven model

The Texas Tech Red Raiders and the Oklahoma State Cowboys are set to square off in a Big 12 matchup at noon ET on Saturday at Boone Pickens Stadium. Oklahoma State is 5-2 overall and 3-1 at home, while the Red Raiders are 3-5 overall and 0-3 on the road. The Red Raiders hold a 23-21-2 edge in the all-time series thanks to back-to-back victories in the last two seasons to stop a nine-year Cowboys winning streak from 2009-2017.

Texas Tech has also covered the spread in each of those victories and has two outright wins this season as underdogs. The Cowboys are favored by 11-points in the latest Oklahoma State vs. Texas Tech odds from William Hill Sportsbook, and the over-under is set at 54. Before entering any Texas Tech vs. Oklahoma State picks, you’ll want to see the college football predictions from the model at SportsLine.

The SportsLine

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Scientists design model to predict cellular drug targets against COVID-19 — ScienceDaily

A computational model of a human lung cell has been used to understand how SARS-CoV-2 draws on human host cell metabolism to reproduce by researchers at the University of Warwick. This study helps understand how the virus uses the host to survive, and enable drug predictions for treating the virus to be made.

Viruses rely on their host to survive, a crucial step of lifecycle is the synthesis of the virus particles within the host cell, therefore understanding this process is key to finding ways to prevent the virus from surviving.

Using a computer model of a human lung cell metabolism, scientists from the School of Life Sciences at the University of Warwick have captured the stoichiometric amino and nucleic acid requirements of SARS-CoV-2, the virus that causes Covid-19. Publishing their results in the paper, ‘Inhibiting the reproduction of SARS-CoV-2 through perturbations in human lung cell metabolic network’, in the

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Scientists apply the METRIC model to estimate land surface evapotranspiration in Nepal

Scientists apply the METRIC model to estimate land surface evapotranspiration in Nepal
Simura station in Nepal. Credit: Weiqiang Ma

Evapotranspiration (ET), the phenomenon of the loss of water into the atmosphere from the land surface through evaporation and transpiration, is an important part of water and energy cycles. ET is a key variable used in applications such as drought monitoring, climate prediction, water resources management, and agricultural planning. The importance of a high-resolution ET estimation has also been well identified for agricultural applications where site-specific monitoring is needed, which is highly relevant for a country like Nepal that relies on agriculture for the majority share of its GDP and employment workforces.


Due to its importance, Prof. Weiqiang Ma from the Institute of Tibetan Plateau Research, Chinese Academy of Sciences, and his group, used the METRIC model to simulate and evaluate the surface evapotranspiration in Nepal. The results have been recently published in Atmospheric and Oceanic Science Letters.

According to the study

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Hackers could steal a Tesla Model X in minutes, security researchers say

It was the latest security experiment from the COSIC group at the University of Leuven in Belgium, which had previously found a similar vulnerability with Tesla’s Model S luxury sedan, where a key fob was also to blame.

The researchers said they were able to break into the SUV, which starts at $80,000, using a few hundred dollars’ worth of equipment.

Researchers noted that process took about 90 seconds.

The researchers, who informed the company of their findings on Aug. 17, said Tesla is rolling out an update intended to address the issue. An over-the-air software update is being pushed to the key fobs, they said, which will better lock them down.

Wired was first to report on the vulnerability. Tesla did not respond to a request for comment.

Lennert Wouters, a PhD student at the COSIC research group, said in an email that the problem is not necessarily unique

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Tesla Model X vulnerable to Bluetooth hack that makes theft mighty simple, report says

Tesla has been made aware of the security holes, which are fixable with over-the-air updates.


Tesla

There’s no denying Tesla vehicles are some of the most connected cars on the road. The electric carmaker championed previously unheard of over-the-air software updates that can roll out new features, updates and essential security upgrades without the owner ever needing to find a service center. Not all is well, however, in the ultraconnected world of Tesla.

Wired reported Monday on significant security oversights that Lennert Wouters, a Belgian security researcher, discovered and informed Tesla of earlier this year. While the hack is apparently simple, that’s not to say anyone could just get away with it. The flaws are severe enough that Tesla will reportedly issue a patch for the vulnerabilities in the coming weeks. Tesla does not operate a public relations department to field requests for comment, but according to Wouters, the

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