New DNA modification ‘signature’ discovered in zebrafish — ScienceDaily

Researchers at the Garvan Institute of Medical Research have uncovered a new form of DNA modification in the genome of zebrafish, a vertebrate animal that shares an evolutionary ancestor with humans ~400 million years ago.

Dr Ozren Bogdanovic and his team discovered that unusually high levels of DNA repeats of the sequence ‘TGCT’ in the zebrafish genome undergo a modification called methylation, which may change the shape or activity of the surrounding DNA. The study, published in Nucleic Acids Research and conducted in collaboration with Queen Mary University of London, could lead to the development of new experimental models for studying how DNA modifications impact human development and disease.

“We’ve revealed a new form of DNA methylation in zebrafish at TGCT repeats, and crucially, the enzyme that makes the modification,” says Dr Bogdanovic, who heads the Developmental Epigenomics Lab at Garvan and Senior Research Fellow at the School of Biotechnology

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