Large multi-site study accurately predicts damage to grey matter by disease — ScienceDaily

An international study has found a link between the brain’s network connections and grey matter atrophy caused by certain types of epilepsy, a major step forward in our understanding of the disease.

In neuroscience, it is becoming increasingly clear that the brain’s connectome is as important as its anatomy when studying human disease. The connectome is a map of neural connections that describes how brain regions interact and work together to perform certain tasks. While connectome research in epilepsy has moved forward in recent years, there is still a lot we do not know about its role in the disorder.

The study, led by researchers from The Neuro (Montreal Neurological Institute-Hospital), analyzed data from 1,021 individuals with epilepsy and 1,564 healthy controls over 19 sites around the world from the ENIGMA database, a collection of neuroimaging data available to researchers under Open Science principles. They used this data to map

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AI abdominal fat measure predicts heart attack and stroke — ScienceDaily

Automated deep learning analysis of abdominal CT images produces a more precise measurement of body composition and predicts major cardiovascular events, such as heart attack and stroke, better than overall weight or body mass index (BMI), according to a study presented today at the annual meeting of the Radiological Society of North America (RSNA).

“Established cardiovascular risk models rely on factors like weight and BMI that are crude surrogates of body composition,” said Kirti Magudia, M.D., Ph.D., an abdominal imaging and ultrasound fellow at the University of California San Francisco. “It’s well established that people with the same BMI can have markedly different proportions of muscle and fat. These differences are important for a variety of health outcomes.”

Unlike BMI, which is based on height and weight, a single axial CT slice of the abdomen visualizes the volume of subcutaneous fat area, visceral fat area and skeletal muscle area. However,

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We could see two new MacBook Pros in 2021, Apple analyst Kuo predicts


Óscar Gutiérrez/CNET

A new investor note from Apple analyst Ming-Chi Kuo predicts two new MacBook Pros will launch in 2021, followed by the release of a more affordable MacBook Air in 2022, 9to5Mac reported Wednesday. The devices are all predicted to use new mini-LED panels, a burnout-resistant improvement to Apple’s LCD screen-lighting technology. The analysis also predicts “two or three” new chargers in 2021, and doubles down on Kuo’s previous estimate of mini-LED unit shipments released in an earlier report. 

In November, Kuo predicted that Apple would release the next generation of MacBook and Apple Watches in the second half of 2021, and that the iPad Air would be given 5G connectivity next year too, as well as a mini-LED display. In the same report, he also said he expect the AirPods 3 launch to be delayed from early next year until April or June. Kuo’s latest analysis revised that

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Bill Gates predicts half of all business travel won’t return once COVID-19 is gone, report says


Bill Gates: Companies will have a “very high threshold” for traveling to conduct in-person meetings.

Screenshot by CNET

Microsoft founder Bill Gates predicts that half of all business travel won’t return after the coronavirus pandemic ends and that people will also work far less often from a physical company office, Business Insider reported. Gates made the remarks Tuesday at The New York Times DealBook conference, BI said.

“My prediction would be that over 50% of business travel and over 30% of days in the office will go away,” Gates reportedly said, adding that from now on, businesses will have a “very high threshold” for traveling to conduct in-person meetings.

Microsoft has already announced a permanent work-from-home policy for eligible employees, who can also choose from a hybrid model

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RBC Predicts Over 100% Rally for These 3 Stocks

The news lately is focused on the advent of coronavirus vaccines. First Pfizer announced that it had a product in trials, which was showing a 90% efficacy rate, and now Moderna has joined the chorus, with a vaccine that is showing even higher effectiveness, on the order of 94.5%. Between the two news releases, investors are feeling confident; we may be out of the COVID woods sooner than has been anticipated.

In a report on the new vaccine announcement, and what they mean for the financial markets, RBC’s analyst Brian Abrahams wrote, “A key focus for investors, and for society overall, has been how quickly immunity will spread throughout the population – either through infection or vaccination – such that transmission will begin to slow and we can start to return to some sense of normalcy. With [the] announcement of positive data from a second vaccine, this reaffirms the potential

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New tool predicts geological movement and the flow of groundwater in old coalfields — ScienceDaily

A remote monitoring tool to help authorities manage public safety and environmental issues in recently abandoned coal mines has been developed by the University of Nottingham.

The tool uses satellite radar imagery to capture millimetre-scale measurements of changes in terrain height. Such measurements can be used to monitor and forecast groundwater levels and changes in geological conditions deep below the earth’s surface in former mining areas.

With a long history of coal mining, the project was tested in the UK at a regional scale, but has global implications given the worldwide decline in the demand for coal in favour of more sustainable energy sources.

The method was implemented over the Nottinghamshire coalfields, which were abandoned as recently as 2015, when the last deep mine, Thoresby Colliery, shut its doors for good.

When deep mines are closed, the groundwater that was previously pumped to the surface to make mining safe, is

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Stanford scientists’ computer model predicts COVID-19 spread in cities

A computer model using cellphone data to map the places people frequent every day in large cities may indicate that most COVID-19 infections occur at “superspreader” sites such as full-service restaurants, gyms and cafes.

The report, published Tuesday in the journal Nature, examined the data of 98 million Americans collected at 10 large U.S. cities, including San Francisco, for two months beginning in March. The data was then fed into an epidemiological model developed by a Stanford University-led team.

Jure Leskovec, the Stanford computer scientist who led the study, told Stanford News that the model analyzed how people of different demographic backgrounds and neighborhoods visited establishments that are more or less crowded.

“Based on all of this, we could predict the likelihood of new infections occurring at any given place or time,” he said.

Those predictions would later prove accurate based on the number of infections officially recorded by the

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Gene signature predicts whether localized prostate cancer is likely to spread — ScienceDaily

Researchers have identified a genetic signature in localized prostate cancer that can predict whether the cancer is likely to spread, or metastasize, early in the course of the disease and whether it will respond to anti-androgen therapy, a common treatment for advanced disease. The new gene signature may also be useful for evaluating responses to treatment and for developing new therapies to prevent or treat advanced prostate cancer.

“If we could know in advance which patients will develop metastases, we could start treatments earlier and treat the cancer more aggressively,” says the study’s senior author, Cory Abate-Shen, PhD, chair of the Department of Molecular Pharmacology and Therapeutics, the Michael and Stella Chernow Professor of Urologic Sciences (in Urology), and professor of pathology & cell biology (in the Herbert Irving Comprehensive Cancer Center) at Columbia University Vagelos College of Physicians and Surgeons.

“Conversely, patients whose disease is likely to remain confined

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A single criterion predicts whether a genetic package such as antibiotic resistance will thrive in a given environment — ScienceDaily

Biomedical engineers at Duke University have developed a new way of modeling how potentially beneficial packages of DNA called plasmids can circulate and accumulate through a complex environment that includes many bacterial species. The work has also allowed the team to develop a new factor dubbed the “persistence potential” that, once measured and computed, can predict whether or not a plasmid will continue to thrive in a given population or gradually fade into oblivion.

The researchers hope that their new model will lay the groundwork for others to better model and predict how important traits such as antibiotic resistance in pathogens or metabolic abilities in bacteria bred to clean environmental pollution will spread and grow in a given environment.

The results appear online on November 4 in the journal Nature Communications.

In addition to the Darwinian process of handing down genes important for survival from parents to offspring, bacteria

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Emerging markets could see an influx of cash following Biden victory, Standard Chartered predicts

  • Emerging markets could benefit from a political environment that looks set to become “more benign” following the victory of Democratic candidate Joe Biden in the U.S. presidential election, predicts Standard Chartered Bank’s Eric Robertsen.
  • “There’s quite a bit of cash sitting on the sidelines and that has been hiding in U.S. assets for a few years,” Robertsen said.
  • With the U.S. appearing “far less likely” to get a large fiscal stimulus package as hopes for a Democratic sweep fade, Invesco’s David Chao said the country’s economic recovery is expected to slow.

Asia to benefit as ‘first port of call’ for emerging markets investors: StanChart



SINGAPORE — Emerging markets could benefit from a political environment that looks set to become “more benign” following the victory of Democratic candidate Joe Biden in the U.S. presidential election, Standard Chartered Bank’s Eric Robertsen predicted.

“There’s quite a bit of

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