Metabolism influences parasite’s resistance to drugs — ScienceDaily

New insight on how a parasite can resist current therapies has been published today in the open-access eLife journal.

The study in cultures of human cells infected with Trypanosoma cruzi (T. cruzi), the parasite that causes Chagas disease, suggests that its metabolic state influences the effectiveness of azole drugs that inhibit its growth. These findings could be useful for the development of more effective antimicrobial treatments.

Chagas disease, also known as American trypanosomiasis, can cause a sudden, brief (acute) illness, or it may be a long-lasting (chronic) condition. Around six to seven million people worldwide are estimated to be infected with the T. cruzi pathogen that causes the disease, according to the World Health Organization. Symptoms can range from mild to severe, but do not often appear until the chronic stage of disease.

“The goal for the treatment of Chagas and other infectious diseases is to eliminate the pathogen

Read More

The discovery can help cure bacterial infections without inducing resistance or causing harm to good bacteria — ScienceDaily

Researchers from the Antimicrobial Resistance (AMR) Interdisciplinary Research Group (IRG) at Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, have developed a method to produce customisable engineered lysins that can be used to selectively kill bacteria of interest while leaving others unharmed. The discovery presents a promising alternative to antibiotics for treating existing drug-resistant bacteria and bacterial infections without the risk of causing resistance.

Lysins are enzymes produced by bacteriophages to break open the bacteria cells while treating infections, and have demonstrated potential as a novel class of antimicrobials. A major advantage of lysins is that they allow fast and targeted killing against specific bacterium of choice without inducing resistance.

The emergence of multidrug-resistant bacteria has left even minor bacterial infections incurable by many existing antibiotics, with at least 700,000 deaths each year due to drug-resistant diseases according to the World Health Organisation.

In a paper

Read More

‘Anti-antibiotic’ allows for use of antibiotics without driving resistance — ScienceDaily

An inexpensive, FDA-approved drug — cholestyramine — taken in conjunction with an antibiotic prevents the antibiotic from driving antimicrobial resistance, according to new research by scientists at Penn State and the University of Michigan. The team’s findings appear today (Dec. 1) in the journal eLife.

“Antimicrobial resistance is a serious problem that has led to people dying from common bacterial infections,” said Andrew Read, Evan Pugh Professor of Biology and Entomology and director of the Huck Institutes of the Life Sciences, Penn State. “Many of our most important antibiotics are failing, and we are beginning to run out of options. We have created a therapy that may help in the fight against antimicrobial resistance, an ‘anti-antibiotic’ that allows antibiotic treatment without driving the evolution and onward transmission of resistance.”

According to Valerie Morley, postdoctoral scholar in the Huck Institutes of the Life Sciences, Penn State, an important cause of

Read More

Italy Fines Apple $12 Million for Misleading iPhone Water Resistance Claims

Apple has been slapped with a 10 million euro ($12 million) fine by Italy’s antitrust watchdog for unfair commercial practices related to its iPhone marketing in the country.

One of the Apple ads cited in the Italian watchdog’s proceedings (credit: setteBIT)

Specifically, Apple is being charged for misleading claims in promotional messages about how deep and how long iPhones can be submerged in water without being damaged.

In marketing materials related to ‌iPhone‌ 8, ‌iPhone‌ 8 Plus, iPhone XR, iPhone XS, ‌iPhone XS‌ Max, iPhone 11, ‌iPhone 11‌ Pro and iPhone 11 Pro Max, Apple said its iPhones were water resistant at a depth of between one and four meters for up to 30 minutes, depending on the model.

However, according to the country’s competition regulator, the messages did not clarify that the claims are only true under specific conditions, for example during controlled laboratory tests with the use

Read More

Experimental evolution reveals how bacteria gain drug resistance — ScienceDaily

A research team at the RIKEN Center for Biosystems Dynamics Research (BDR) in Japan has succeeded in experimentally evolving the common bacteria Escherichia coli under pressure from a large number of individual antibiotics. In doing so, they were able to identify the mechanisms and constraints underlying evolved drug resistance. Their findings, published in the scientific journal Nature Communications, can be used to help develop drug-treatment strategies that minimize the chance that bacteria will develop resistance.

Counteracting multidrug-resistant bacteria is becoming a critical global challenge. It seems that every time we develop new antibiotics, novel antibiotic-resistant bacteria emerge during clinical use. To win this cat-and-mouse game, we must understand how drug resistance evolves in bacteria. Naturally, this process is very complicated, involving numerous changes in genome sequences and cellular states. Therefore, a comprehensive study of resistance dynamics for large numbers of antibiotics has never been reported.

“Laboratory evolution combined with

Read More

How the TB bacterium develops rapid resistance to antibiotics — ScienceDaily

For a slow-growing microbe that multiplies infrequently, Mycobacterium tuberculosis, the pathogen that causes tuberculosis (TB) has long puzzled researchers as to how it develops resistance to antibiotics so quickly, in a matter of weeks to months.

Now, TB researchers at San Diego State University have uncovered a crucial clue to the mystery: the answer may lie in the epigenetic domain rather than the genetic domain where most scientists have concentrated their efforts.

Their discovery could help advance new diagnostics, therapeutics and vaccine targets.

Epigenetics is the study of inheritable changes in gene expression that do not involve a corresponding change to the underlying DNA sequence — meaning changes to the phenotype but no change in the genotype. This affects only the physical structure of the DNA, through a process called DNA methylation where a chemical ‘cap’ is added to the DNA molecule, preventing or facilitating the expression of certain

Read More

Alzheimer’s disease drug may help fight against antibiotic resistance — ScienceDaily

An experimental Alzheimer’s disease treatment is proving effective at treating some of the most persistent, life-threatening antibiotic-resistant bacteria.

Researchers from The University of Queensland, The University of Melbourne and Griffith University have discovered that the drug called PBT2 is effective at disrupting and killing a class of bacteria — known as Gram-negative bacteria — that cause infections such as pneumonia, bloodstream infections and meningitis.

UQ’s Professor Mark Walker said the metal transport drug may offer a last line of defence against some of the world’s most difficult to treat superbugs.

“The emergence of antibiotic-resistant superbugs is an urgent threat to human health, undermining the capacity to treat patients with serious infection,” Professor Walker said.

“Alternative strategies to treat such multi-drug resistant bacteria are urgently needed.

“Led by UQ’s Dr David De Oliveira, our team hypothesised that, by using this experimental Alzheimer’s treatment to disrupt the metals inside these bacteria, we

Read More

This Is Cisco’s Must-Watch Resistance Level After Earnings Pop

Cisco Systems  (CSCO) – Get Report was up more than 6.5% on Friday after the company delivered better-than-expected earnings.

The rally sent the stock to its highest point since early September as Cisco has had a lot of trouble gaining upside traction over the last few months.

Shares were buried in August, falling more than 11% in one day on disappointing earnings. Since then, the stock has been in a nasty downtrend.

However, Cisco gapped up on Monday and even though most of those gains faded by the close it set the tone for a strong week.

The company delivered a top- and bottom-line beat on Thursday after the close, with guidance for both earnings and revenue for next quarter also topping expectations.

Analysts loved the results, giving the stock a nod after the print. Can Cisco keep up the momentum? Let’s look at the chart.

Trading Cisco

Read More

Chemical clues in leaves can reveal ash tree resistance to deadly disease — ScienceDaily

Naturally occurring compounds in ash leaves could be linked to susceptibility of individual trees to the fungal disease ash dieback (ADB). But selecting trees with lower levels of these compounds and breeding for resistance could leave the UK ash tree population open to attack from invading insect pests in the future, according to scientists at the University of Warwick.

Secoiridoid glycosides are naturally occurring compounds found in plant leaves. Researchers from Warwick’s School of Life Sciences and Department of Chemistry and the School of Biosciences at the University of Exeter looked at the abundance and diversity of secoiridoid glycosides in the leaves of a panel of ash trees known to be resistant and samples from trees known to be susceptible to ADB from both Denmark and the UK.

Previous research had identified five compounds in the secoiridoid glycoside family that were enriched in susceptible Danish trees, but results published today

Read More

Low Rolling Resistance Tire Market- Global Market Size, Rising Demand,Trends, Astonishing Growth,Technology And Future Opportunities, 2027

The MarketWatch News Department was not involved in the creation of this content.

New York, United States, Tue, 10 Nov 2020 02:51:55 / Comserve Inc. / — Global low rolling resistance tire market is anticipated to record a CAGR of 12.3% over the forecast period.

Recent report published by research nester titled “Low Rolling Resistance Tire Market: Global Demand Analysis & Opportunity Outlook 2027” delivers the detailed overview of the global low rolling resistance tire market in terms of market segmentation by type, by vehicle, by sales channel and by region.

Further, for the in-depth analysis, the report encompasses the industry growth drivers, restraints, supply and demand risk, market attractiveness, BPS analysis and Porter’s five force model.

Get Exclusive Sample Report Copy Of This Report @

The market is segmented on the basis of type, vehicle and sales channel. On the basis of type, it is sub-segmented into bias,

Read More