A repetitive DNA sequence that causes health risks when it malfunctions can now be watched inside living cells using a synthetic tool — ScienceDaily

A new synthetic probe offers a safe and straightforward approach for visualizing chromosome tips in living cells. The probe was designed by scientists at the Institute for Integrated Cell-Material Science (iCeMS) and colleagues at Kyoto University, and could advance research into aging and a wide range of diseases, including cancers. The details were published in the Journal of the American Chemical Society.

“Chromosome ends are constantly at risk of degradation and fusion, so they are protected by structures called telomeres, which are made of long repeating DNA sequences and bound proteins,” says iCeMS chemical biologist Hiroshi Sugiyama, who led the study. “If telomeres malfunction, they are unable to maintain chromosome stability, which can lead to diseases such as cancer. Also, telomeres normally shorten with each cell division until they reach their limit, causing cell death.”

Visualizing telomeres, especially their physical arrangements in real-time, is important for understanding their relevance

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Scientists Sequence DNA Of 240 Mammals

An international team of scientists has sequenced the genomes of 240 species of mammals. 

Their publicly available dataset, which contains genomes of mammals ranging from the bumblebee bat to the black rhinoceros, including many endangered species, is the largest and most comprehensive of its kind generated to date. These data will help scientists learn which genetic mutations cause human diseases like cancer. 

The Zoonomia Project has analyzed the genomes of mammals over about 110 million years of evolution. A paper about the dataset is published in Nature.

“The core idea for the project was to develop and use this data to help human geneticists figure out which mutations cause disease,” Kerstin Lindblad-Toh, a senior co-author of the study and a professor in comparative genomics at Uppsala University, said in a news release.

Scientists can

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