T-cell abnormalities in severe COVID-19 cases — ScienceDaily

There is an idea within the coronavirus research field that there is some kind of T cell abnormality in critically ill COVID-19 patients, but specific details have not yet been clarified. To shed light on the problem, a research collaboration based in Kumamoto University (Japan) has performed a genetic analysis of T cells from lung tissue of COVID-19 patients. Their work revealed abnormalities in T cells that resulted in overactivation that may cause severe pneumonia. The researchers believe that their findings will lead to new ways of avoiding severe pneumonia caused by coronavirus infections.

COVID-19 continues to have an enormous impact on daily lives. Why some people become severely ill while the majority of those infected are asymptomatic or very mildly ill is still a major unanswered question. Risk factors for severe disease include old age, diabetes, obesity, and hypertension. We also know that critically ill patients experience an increase

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No benefit seen from plasma treatment in severe COVID-19; virus may hurt male fertility

(Reuters) – The following is a roundup of some of the latest scientific studies on the novel coronavirus and efforts to find treatments and vaccines for COVID-19, the illness caused by the virus.

FILE PHOTO: Convalescent plasma samples in vials are seen before being tested for COVID-19 antibodies at the Bloodworks Northwest Laboratory during the coronavirus disease (COVID-19) outbreak in Renton, Washington, U.S. September 9, 2020. REUTERS/Lindsey Wasson

Plasma treatment shows no benefit in severe COVID-19

Blood plasma from COVID-19 survivors was of little benefit to patients with severe COVID-19 pneumonia, researchers in Argentina reported on Tuesday in The New England Journal of Medicine. So-called convalescent plasma, which delivers COVID-19 survivors’ antibodies to infected people, did not improve critically ill patients’ health status or reduce their risk of dying from the disease any better than a placebo. Researchers randomly assigned 333 hospitalized patients with severe COVID-19 pneumonia to receive convalescent

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Drug eases recovery for those with severe alcohol withdrawal — ScienceDaily

A drug once used to treat high blood pressure can help alcoholics with withdrawal symptoms reduce or eliminate their drinking, Yale University researchers report Nov. 19 in the American Journal of Psychiatry.

In a double-blind study, researchers gave the drug prazosin or a placebo to 100 people entering outpatient treatment after being diagnosed with alcohol use disorder. All of the patients had experienced varying degrees of withdrawal symptoms prior to entering treatment.

According to the researchers, subjects with more severe symptoms — including shakes, heightened cravings and anxiety, and difficulty sleeping — who received prazosin significantly reduced the number of heavy drinking episodes and days they drank compared to those who received a placebo. The drug had little effect on those with few or no withdrawal symptoms.

“There has been no treatment readily available for people who experience severe withdrawal symptoms and these are the people at highest risk

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CLCN6 identified as disease gene for a severe form of lysosomal neurodegenerative disease — ScienceDaily

A mutation in the CLCN6 gene is associated with a novel, particularly severe neurodegenerative disorder. Scientists from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and the Max Delbrück Center für Molekulare Medizin (MDC), together with an international team of researchers, have now analyzed the effect of a point mutation that was found in three unrelated affected children. ClC-6 is one of nine members of the CLCN gene family of chloride channels and chloride/proton exchangers and, apart from ClC-3, was the only one that could not yet be associated with any human disease. The results have just been published in the American Journal of Human Genetics.

The term “lysosomal storage disease” summarizes a number of genetically determined metabolic diseases that are due to incorrect or insufficient function of lysosomes. These cellular organelles are important both as “cellular waste disposal” and for the regulation of cellular metabolism. If lysosomal function is compromised,

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How rotavirus causes severe gastrointestinal disease — ScienceDaily

Rotavirus is a major cause of diarrhea and vomiting, especially in children, that results in approximately 128,000 deaths annually. The virus triggers the disease by infecting enterocyte cells in the small intestine, but only a fraction of the susceptible cells has the virus. In the mid-90s, scientists proposed that the small portion of infected cells promotes severe disease by sending out signals that disrupt the normal function of neighboring uninfected cells, but the nature of the signal has remained a mystery.

In the current study published in the journal Science, a team led by researchers at Baylor College of Medicine discovered that rotavirus-infected cells release signaling molecules, identified as adenosine diphosphate (ADP), which binds its cellular receptor P2Y1 on neighboring cells. Activating P2Y1 by ADP results in signals called intercellular calcium waves in these uninfected cells. Disrupting ADP binding to its receptor reduced the severity of diarrhea in a

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More Frequent, Severe Climate-Fueled Disasters Exacerbate Humanitarian Crises

Extreme weather and climate-linked disasters have killed 410,000 people since 2010, according to the International Federation of Red Cross and Red Crescent Societies.

The group’s “World Disasters Report 2020” released yesterday says more frequent and severe catastrophes threaten to exacerbate humanitarian crises and lead to economic hardship even as global death counts drop because of steps to improve resilience.

The relief organization warns that major disasters are increasingly happening in succession, such as the half-dozen typhoons and tropical storms that have hit Southeast Asia since early October.

By combing through data on thousands of disasters the federation has responded to in the past decade, IFRC says that 83% of them were climate-related in some way, usually severe flooding, violent storms and deadly heat waves.

“The number of such disasters triggered by extreme weather- and climate-related events has been increasing since the 1960s, and has risen almost 35% since the 1990s,”

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Manufacturing Industry at High Risk of Severe Impact from COVID-19 Pandemic

Print & publishing, Industrial Equipment, Apparel, and Textile Products among the top 5 most affected sectors

The State of the Manufacturing Industry Q3: A COVID-19 Impact Study
The State of the Manufacturing Industry Q3: A COVID-19 Impact Study
The State of the Manufacturing Industry Q3: A COVID-19 Impact Study

Allentown, PA, Nov. 16, 2020 (GLOBE NEWSWIRE) — The manufacturing industry in the United States is standing at the precipice of severe negative impacts due to COVID-19, according to a new report from the global business intelligence experts, Creditsafe. According to the report, many manufacturers could see a significant decrease in their revenue, which may bring about difficult decisions on how best to navigate these difficult times.  

 

The data shows that the following manufacturing sectors are the most likely to be severely impacted. 

 

  • Printing and Publishing

  • Miscellaneous Manufacturing

  • Industrial Machinery and Equipment

  • Fabricated Metal Products

  • Apparel and Other Textile Products 

 

When combined, these industries represent over half a million businesses across the

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COVID-19: New protein treatment ‘reduces odds of developing severe’ coronavirus | Science & Tech News, Reports

A new inhaled protein treatment has been found to accelerate recovery and lower the odds of developing severe COVID-19 in patients, researchers have said.

Small-scale trial results for the drug, known as SNG001, suggest that users were more than twice as likely to recover from COVID-19, compared to those who had the placebo drug.

The drug, which was developed by Southampton-based biotech Synairgen, contains interferon beta-1a – a protein naturally produced by the body to fight viral infections.

Image:
The protein is taken through a nebuliser

SNG001 is inhaled using a nebuliser, in an attempt to trigger an immune response.

Scientists say their findings, which have been published in The Lancet Respiratory Medicine journal, are proof-of-concept that the drug could help coronavirus patients in hospital recover.

However, the group note that more research is required with a larger, randomised clinical trial, as their study only involved 98

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Severe COVID-19 infection rare in newborns, study finds — ScienceDaily

Severe COVID-19 infection appears rare in newborn babies, suggests a new study.

The UK-wide analysis, led by researchers from Imperial College London and the Nuffield Department of Population Health at the University of Oxford, is the first study analysing COVID-19 infections in newborns across the whole UK.

The study, published in the journal The Lancet Child and Adolescent Health, traced all babies less than 29 days old with COVID-19 across the UK, who needed to be admitted into hospital.

The analysis, which was funded by the National Institute for Health Research, traced these babies with COVID-19 between the beginning of March and end of April, at the peak of the first wave of the UK COVID-19 pandemic. Babies were tracked using a national system called the British Paediatric Surveillance Unit that all paediatricians in the UK contribute to.

The study found 66 babies required hospital treatment for COVID-19 infection

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