A repurposed mouse model can develop symptoms of both severe COVID-19 (lung damage, blood clots, abnormal blood vessels, and death) and also of milder disease, including loss of the sense of smell, according to a recent University of Iowa study published in Nature.
The study also showed that convalescent plasma from a patient who had recovered from COVID-19 protected the mice against lethal disease. The findings suggest the K18-hACE2 mouse model is useful for understanding a spectrum of COVID-19 disease symptoms, and for developing and testing new treatments.
When COVID-19 started spreading across the world earlier this year, UI researchers Stanley Perlman, MD, PhD, and Paul McCray, MD, realized that a mouse model they had created a decade earlier to study SARS might be an invaluable tool for understanding the concerning new disease and for testing potential treatments.
In the new study, Perlman, McCray, and colleagues present a detailed characterization